Artificial Cellular Systems Lab (The ArtCs Lab)

Understanding and controlling Artificial Cellular Systems for Biomedical Applications

It is challenging to create active and smart artificial cellular systems that rival the dynamic chemical-biological response and resilience of natural cells. The artificial cellular systems (also called biohybrid or biomimetic cells) are hybrid material-bacteria systems that have broad applications in energy production, disease treatment, and basic biological study. To overcome the challenge, we investigate the operating principles of protein and gene networks. We apply the principles to control various artificial cellular systems, including synthetic bacteria, cell-free, artificial bacteria, and hybrid cell-soft robots. We use a unique holistic approach that integrates synthetic biology and systems biology. Our work will lead to effective and efficient artificial cellular systems for both biotech applications and disease treatment.

Recent Publication

Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits
Luis E. Contreras-Llano, Conary Meyer, Yao Liu, Mridul Sarker, Sierin Lim, Marjorie L. Longo, C. Tan
Nature Communications, pdf

Latest News

Feb 2019 Prof Tan was awarded the NIH – NIBIB Trailblazer Award. press

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